In a recent interview with Entertainment Weekly, Bruckheimer revealed that he has spoken to Depp about coming back for the sixth Pirates film, and the actor is at least open to the idea. The famous Producer explained: If he likes the way the part's written,

Pirates of the Caribbean's creator has revealed Johnny Depp could return to the film series but has one condition for his return

A female-led Pirates of the Caribbean 6 starring Margot Robbie has been discussed. Though Robbie later said the film was no longer in development, Bruckheimer has still sometimes mentioned it as a possibility. There were also rumors of Disney hoping to cast Karen Gillan in a sixth film.