Nov 5, 2021 · This disclosure provides methods and compositions for detecting intramolecular and intermolecular interactions, such as protein-protein interactions. These methods detect …

Jan 11, 2021 · In this review, we summarize the basic principles of PLA and its applications in pathogen detection. Key Points • Different forms of proximity ligation assay are introduced. • …

Duolink ® Proximity Ligation Assay Duolink ® Proximity Ligation Assay (PLA) is a powerful tool that allows in situ detection of endogenous proteins, protein modifications, and protein …

Mar 15, 2019 · To complement these approaches, increased utilization of super resolution imaging, Förster resonance energy transfer (FRET), fluorescence correlation spectroscopy …

Protein–protein interactions (PPI) by homo-, hetero- or oligo-merization in the cellular environment regulate cellular processes. PPI can be inhibited by antibodies, small molecules or peptides, …

Introduction to Proximity Ligation Assays (PLA) Proximity Ligation Assay (PLA) is a highly sensitive molecular biology technique designed to detect and visualize protein-protein …

Ola Södergren et al. first described the application of the in situ proximity ligation technology for localized protein detection in 2006.The authors used the method for localizing proteins and …

Apr 29, 2025 · Explore the principles and applications of proximity ligation assay, a highly sensitive method for detecting protein interactions with precision and versatility.

Oct 6, 2024 · Purpose Current bulk molecular assays fail to capture spatial signaling activities in cancers, limiting our understanding of drug resistance mechanisms. We developed a graph …

Abstract Proximity ligation assay (PLA), also referred to as Duolink ® PLA technology, permits detection of protein–protein interactions in situ (<40 nm distance) at endogenous protein …